The 2023 Challenger Santa Fe was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2023 ATP Challenger Tour. It took place in Santa Fe, Argentina between 3 and 9 July 2023.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Mariano Navone | 190 | 1 | |
| Argentina | Santiago Rodríguez Taverna | 228 | 2 | |
| Argentina | Román Andrés Burruchaga | 238 | 3 | |
| Argentina | Francisco Comesaña | 242 | 4 | |
 Brazil | Gustavo Heide | 338 | 5 | |
| Brazil | Eduardo Ribeiro | 344 | 6 | |
 Peru | ||||
| Brazil | Pedro Boscardin Dias | 414 | 8 | |
| Argentina | Matías Franco Descotte | 426 | 9 |
The following players received wildcards into the singles main draw:
Alejo Lorenzo Lingua Lavallén Lucio RattiThe following players received entry into the singles main draw as alternates:
Preston Brown Juan Manuel La SernaThe following players received entry from the qualifying draw:
Lautaro Corthey Igor Gimenez
Álvaro Guillén Meza Luciano TacchiThe following player received entry as a lucky loser:
See main article: 2023 Challenger Santa Fe – Singles.
Mariano Navone def. Daniel Vallejo 6–2, 6–4.See main article: 2023 Challenger Santa Fe – Doubles.
Vasil Kirkov / Matías Soto def. Ignacio Carou / Ignacio Monzón 7–6(7–3), 6–2.