| Date: | 25 April–1 May 2022 |
| Edition: | 12th |
| Surface: | Clay / Outdoor |
| Location: | Zagreb, Croatia |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: | Jule Niemeier |
| Champd: |  Anastasia Dețiuc /  Katarina Zavatska |
The 2022 Zagreb Ladies Open was a professional tennis tournament played on outdoor clay courts. It was the twelfth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Zagreb, Croatia between 25 April and 1 May 2022.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Donna Vekić | 107 | 1 | ||
| Jule Niemeier | 108 | 2 | ||
 Hungary | Réka Luca Jani | 140 | 3 | |
 Argentina | Paula Ormaechea | 150 | 4 | |
| Polona Hercog | 164 | 5 | ||
| Despina Papamichail | 173 | 6 | ||
| Anna-Lena Friedsam | 184 | 7 | ||
| Czech Republic | Linda Nosková | 188 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2022 Zagreb Ladies Open – Singles.
Réka Luca Jani, 6–2, 6–2See main article: 2022 Zagreb Ladies Open – Doubles.
Anastasia Dețiuc / Katarina Zavatska def. 
Lina Gjorcheska / Irina Khromacheva, 6–4, 6–7(5–7), [11–9].