The men's 50m butterfly events at the 2022 World Para Swimming Championships were held at the Penteada Olympic Swimming Complex in Madeira between 12–18 June.
| S5 | Samuel da Silva de Oliveira Brazil | Kaede Hinata Japan | Siyazbek Daliyev Kazakhstan | |
| S6 | Laurent Chardard France | Nelson Crispín Colombia | David Sanchez Sierra Spain | |
| S7 | Andrii Trusov Ukraine | Carlos Serrano Zárate Colombia | Iñaki Basiloff Argentina |
| Rank | Athlete | Nation | Result | Notes | ||
|---|---|---|---|---|---|---|
| 33.23 | ||||||
| 35.06 | ||||||
| 36.32 | ||||||
| 4 | 36.87 | |||||
| 5 | 38.72 | |||||
| 6 | 39.19 | |||||
| 7 | 41.63 | |||||
| data-sort-value=9:99.99 |