See main article: article and 2022 Winston-Salem Open.
Adrian Mannarino defeated Laslo Đere in the final, 7–6(7–1), 6–4 to win the singles tennis title at the 2022 Winston-Salem Open. Mannarino saved four match points en route to the title, in his first-round match against Christopher O'Connell.
Ilya Ivashka was the defending champion, but lost in the third round to Marc-Andrea Hüsler.[1]
All seeds receive a bye into the second round.