| Year: | 2022 |
| Team: | Western Illinois Leathernecks |
| Sport: | football |
| Conference: | Missouri Valley Football Conference |
| Short Conf: | MVFC |
| Record: | 0–11 |
| Conf Record: | 0–8 |
| Head Coach: | Myers Hendrickson |
| Hc Year: | 1st |
| Def Coach: | Todd Drury |
| Dc Year: | 1st |
| Stadium: | Hanson Field |
The 2022 Western Illinois Leathernecks football team represented Western Illinois University as a member of the Missouri Valley Football Conference (MVFC) during the 2022 NCAA Division I FCS football season. They were led by first-year head coach Myers Hendrickson. The Leathernecks played their home games at Hanson Field in Macomb, Illinois.
See also: 2022 UT Martin Skyhawks football team.
See also: 2022 Minnesota Golden Gophers football team.
See also: 2022 Southern Utah Thunderbirds football team.
See also: 2022 Northern Iowa Panthers football team.
See also: 2022 South Dakota State Jackrabbits football team.
See also: 2022 Southern Illinois Salukis football team.
See also: 2022 Youngstown State Penguins football team.
See also: 2022 Missouri State Bears football team.
See also: 2022 North Dakota State Bison football team.
See also: 2022 Indiana State Sycamores football team.
See also: 2022 Illinois State Redbirds football team.