| Before Year: | 2021 |
| Champ: |  Zhang Shuai |
| Runner: |  Dayana Yastremska |
| Score: | 3–6, 6–3, 6–4 |
| Draw: | 32 |
| Seeds: | 8 |
| Type: | Singles Doubles |
| After Year: | 2023 |
See main article: 2022 WTA Lyon Open.
Zhang Shuai defeated wildcard Dayana Yastremska in the final, 3–6, 6–3, 6–4 to win the Singles title at the 2022 WTA Lyon Open.[1] It was her first title since 2017. Yastremska was participating in her first event since fleeing her native country of Ukraine due to the 2022 Russian invasion of Ukraine.[2]
Clara Tauson was the defending champion,[3] but chose not to participate.