| Date: | 28 February – 6 March |
| Edition: | 3rd |
| Category: | WTA 250 |
| Draw: | 32S / 16D |
| Surface: | Hard (Indoor) |
| Prize Money: | $239,447 |
| Location: | Lyon, France |
| Venue: | Palais des Sports de Gerland |
| Champs: |  Zhang Shuai |
| Champd: | Laura Siegemund / Vera Zvonareva |
The 2022 WTA Lyon Open (also known as the Open 6ème Sens — Métropole de Lyon for sponsorship reasons) was a women's tennis tournament played on indoor hard courts. It was the third edition of the Lyon Open (WTA) and an International tournament on the 2022 WTA Tour. It took place at the Palais des Sports de Gerland in Lyon, France, from February 28th to March 6th, 2022.[1] During this tournament, the WTA and other international governing bodies of tennis including the ATP did not have players of Russia and Belarus compete under their country's flags as a result of the Russian invasion of Ukraine.[2]
See main article: article and 2022 WTA Lyon Open – Singles.
Zhang Shuai def. 
Dayana Yastremska 3–6, 6–3, 6–4This is Zhang's first WTA Tour singles title since 2017, and third overall.
See main article: article and 2022 WTA Lyon Open – Doubles.
Alicia Barnett / Olivia Nicholls 7–5, 6–1| Country | Player | Ranking1 | Seed | |
|---|---|---|---|---|
 Italy | Camila Giorgi | 30 | 1 | |
 Romania | Sorana Cîrstea | 31 | 2 | |
| Viktorija Golubic | 36 | 3 | ||
 France | Alizé Cornet[3] | 37 | 4 | |
| Italy | Jasmine Paolini | 44 | 5 | |
| Ana Konjuh | 51 | 6 | ||
 Belgium | Alison Van Uytvanck | 53 | 7 | |
| China | Zhang Shuai | 65 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry using a protected ranking into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
Kristina Mladenovic Irina-Camelia Begu → replaced by Irina Bara Jaqueline Cristian → replaced by Ana Bogdan
Tereza Martincová → replaced by Vitalia Diatchenko Markéta Vondroušová → replaced by Martina Trevisan Maryna Zanevska → replaced by 
Mai Hontama| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Japan | Eri Hozumi | Japan | Makoto Ninomiya | 78 | 1 | |
| Chan Hao-ching | Julia Lohoff | 120 | 2 | |||
| Romania | Irina Bara |  Georgia | Ekaterine Gorgodze | 124 | 3 | |
| Romania | Monica Niculescu | Alexandra Panova | 127 | 4 |
The following pairs received wildcards into the doubles main draw:
Tímea Babos / Chan Hao-ching → replaced by 
Georgina García Pérez / Xenia Knoll
Ulrikke Eikeri → replaced by Ulrikke Eikeri / Samantha Murray Sharan
Sania Mirza / Zhang Shuai → replaced by Estelle Cascino / Jessika Ponchet Samantha Murray Sharan / Bibiane Schoofs → replaced by Alicia Barnett / Olivia Nicholls