| Date: | 19–25 September 2022 |
| Edition: | 10th |
| Surface: | Clay / Outdoor |
| Location: | Vrnjačka Banja, Serbia |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Aliona Bolsova |
| Champd: | Darya Astakhova / Ekaterina Reyngold |
| Before Name: | Vrnjačka Banja Open 1 |
| Before Year: | 2022 |
The 2022 Vrnjačka Banja Open was a professional tennis tournament played on outdoor clay courts. It was the tenth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Vrnjačka Banja, Serbia between 19 and 25 September 2022.[1]
See main article: 2022 Vrnjačka Banja Open – Singles.
Aliona Bolsova def. Nina Potočnik, 7–5, 6–1See main article: 2022 Vrnjačka Banja Open – Doubles.
Cristina Dinu / Nika Radišić, 3–6, 6–2, [10–8]| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Elina Avanesyan | 131 | 1 | ||
| Romania | Alexandra Cadanțu-Ignatik | 168 | 2 | |
 Australia | Jaimee Fourlis | 169 | 3 | |
 France | Elsa Jacquemot | 188 | 4 | |
 Austria | Sinja Kraus | 198 | 5 | |
| Tena Lukas | 200 | 6 | ||
| France | Séléna Janicijevic | 203 | 7 | |
 Turkey | İpek Öz | 204 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following player received entry into the singles main draw as a special exempt:
Misaki MatsudaThe following players received entry from the qualifying draw:
Jessie Aney Oana Gavrilă Zeynep Sönmez
Radka ZelníčkováThe following player received entry as a lucky loser:
Mila Mašić