| Date: | 7–13 November |
| Edition: | 17th |
| Surface: | Clay |
| Venue: | Carrasco Lawn Tennis Club |
| Location: | Montevideo, Uruguay |
| Category: | ATP Challenger 80 |
| Champs: |  Genaro Alberto Olivieri |
| Champd: |  Karol Drzewiecki / Piotr Matuszewski |
The 2022 Uruguay Open was a professional tennis tournament played on red clay courts in Montevideo. It was the 17th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place at the Carrasco Lawn Tennis Club in Montevideo, Uruguay between 7 and 13 November 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Argentina | ||||
| Argentina | Tomás Martín Etcheverry | 83 | 2 | |
| Daniel Altmaier | 91 | 3 | ||
| Argentina | Facundo Bagnis | 101 | 4 | |
 Italy | Marco Cecchinato | 109 | 5 | |
| Argentina | Camilo Ugo Carabelli | 123 | 6 | |
| Argentina | Juan Manuel Cerúndolo | 151 | 7 | |
| Italy | Franco Agamenone | 154 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2022 Uruguay Open – Singles.
Genaro Alberto Olivieri def. Tomás Martín Etcheverry 6–7(3–7), 7–6(7–5), 6–3.See main article: 2022 Uruguay Open – Doubles.
Karol Drzewiecki / Piotr Matuszewski def. Facundo Díaz Acosta / 
Luis David Martínez 6–4, 6–4.
