The 2022 UniCredit Czech Open was a professional tennis tournament played on clay courts. It was the 29th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Prostějov, Czech Republic between 30 May and 4 June 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Federico Coria | 54 | 1 | |
 Czech Republic | ||||
| Czech Republic | ||||
 Spain | Pablo Andújar | 98 | 4 | |
 Slovakia | Norbert Gombos | 112 | 5 | |
 Sweden | Elias Ymer | 127 | 6 | |
| Slovakia | Andrej Martin | 128 | 7 | |
| Czech Republic | Zdeněk Kolář | 134 | 8 |
The following players received wildcards into the singles main draw:
Martin Krumich
Hamad Međedović Lukáš PokornýThe following player received entry into the singles main draw as a special exempt:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
See main article: 2022 UniCredit Czech Open – Singles.
Vít Kopřiva def. Dalibor Svrčina 6–2, 6–2.See main article: 2022 UniCredit Czech Open – Doubles.
Yuki Bhambri / Saketh Myneni def. Roman Jebavý / Andrej Martin 6–3, 7–5.
