| Date: | 11–17 April 2022 |
| Edition: | 7th |
| Surface: | Clay / Outdoor |
| Location: | Palm Harbor, Florida, United States |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $100,000 |
| Champs: |  Katie Volynets |
| Champd: | Sophie Chang / Angela Kulikov |
| Before Name: | Innisbrook Open |
| Before Year: | 2019 |
The 2022 U.S. Pro Women's Clay Court Championships was a professional tennis tournament played on outdoor clay courts. It was the seventh edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Palm Harbor, Florida, United States between 11 and 17 April 2022.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 China | Wang Xinyu | 88 | 1 | |
 Australia | ||||
 Romania | Irina Bara | 118 | 3 | |
| United States | Hailey Baptiste | 124 | 4 | |
| China | Wang Xiyu | 149 | 5 | |
| United States | Alycia Parks | 150 | 6 | |
| Anastasia Gasanova | 153 | 7 | ||
| United States | Katie Volynets | 154 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Hanna Chang
Salma Djoubri Elvina Kalieva Gabriela Lee Maegan Manasse Seone Mendez Whitney Osuigwe
María José Portillo RamírezThe following player received entry as a lucky loser:
See main article: 2022 U.S. Pro Women's Clay Court Championships – Singles.
Katie Volynets def. Wang Xiyu 6–4, 6–3See main article: 2022 U.S. Pro Women's Clay Court Championships – Doubles.
Sophie Chang / Angela Kulikov def. Irina Bara / 
Lucrezia Stefanini 6–4, 3–6, [10–8]