| Date: | 16–21 May |
| Edition: | 12th |
| Surface: | Clay |
| Location: | Tunis, Tunisia |
| Champs: |  Roberto Carballés Baena |
| Champd: |  Nicolás Barrientos /  Miguel Ángel Reyes-Varela |
| Before Year: | 2019 |
The 2022 Tunis Open was a professional tennis tournament played on clay courts. It was the 12th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Tunis, Tunisia between 16 and 21 May 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Australia | Jordan Thompson | 85 | 1 | |
| Spain | Roberto Carballés Baena | 96 | 2 | |
| Spain | Javier Barranco Cosano | 251 | 3 | |
| Frederico Ferreira Silva | 255 | 4 | ||
| Jelle Sels | 256 | 5 | ||
| Nicola Kuhn | 258 | 6 | ||
 China | Zhang Zhizhen | 261 | 7 | |
 Belgium | Kimmer Coppejans | 267 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
See main article: 2022 Tunis Open – Singles.
Roberto Carballés Baena def. Gijs Brouwer 6–1, 6–1.See main article: 2022 Tunis Open – Doubles.
Nicolás Barrientos / Miguel Ángel Reyes-Varela def. 
Alexander Erler / Lucas Miedler 6–7(3–7), 6–3, [11–9].
