| Date: | 3–9 October |
| Edition: | 14th |
| Surface: | Hard |
| Location: | Tiburon, United States |
| Champs: |  Zachary Svajda |
| Champd: | Leandro Riedi / Valentin Vacherot |
| Before Year: | 2019 |
The 2022 Tiburon Challenger was a professional tennis tournament played on outdoor hard courts. It was the fourteenth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Tiburon, United States between October 3 and October 9, 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| United States | Denis Kudla | 100 | 1 | |
| United States | Stefan Kozlov | 127 | 2 | |
| United States | Michael Mmoh | 134 | 3 | |
| United States | Ben Shelton | 177 | 4 | |
 France | Enzo Couacaud | 187 | 5 | |
 China | Shang Juncheng | 197 | 6 | |
| United States | Ernesto Escobedo | 200 | 7 | |
| United States | Mitchell Krueger | 207 | 8 |
The following players received wildcards into the singles main draw:
Jonas Eriksson Ziverts Patrick Kypson Sam RifficeThe following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Nick Chappell Evan King Christian Langmo Alex Michelsen
Luke SavilleSee main article: article and 2022 Tiburon Challenger – Singles.
Zachary Svajda def. Ben Shelton 2–6, 6–2, 6–4.See main article: article and 2022 Tiburon Challenger – Doubles.
Ezekiel Clark / Alfredo Perez 6–7(2–7), 6–3, [10–2].