| Date: | 26 September – 2 October |
| Edition: | 18th |
| Category: | ATP Tour 250 series |
| Prize Money: | $949,475 |
| Draw: | 28S / 16D |
| Surface: | Hard (indoor) |
| Location: | Tel Aviv, Israel |
| Venue: | Expo Tel Aviv |
| Champs: |  Novak Djokovic |
| Champd: |  Rohan Bopanna / Matwé Middelkoop |
| Before Year: | 1996 |
| After Year: | no |
The 2022 Tel Aviv Open (also known as the 2022 Tel Aviv Watergen Open for sponsorship purposes) was a tennis tournament played on indoor hard court. It was the first edition of the Tel Aviv Open at the ATP Tour level since 1996 (18th overall), and part of the ATP Tour 250 series of the 2022 ATP Tour. It was played at Expo Tel Aviv in Tel Aviv, Israel, from 26 September to 2 October 2022.[1] [2]
The event was primarily organized due to the cancellation of tournaments in China during the 2022 season because of the ongoing COVID-19 pandemic.[3]
See main article: 2022 Tel Aviv Open – Singles.
Novak Djokovic def. Marin Čilić, 6–3, 6–4See main article: 2022 Tel Aviv Open – Doubles.
Rohan Bopanna / Matwé Middelkoop def. 
Santiago González / 
Andrés Molteni, 6–2, 6–4| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Serbia | Novak Djokovic | 7 | 1 | |
| Marin Čilić | 16 | 2 | ||
| Argentina | Diego Schwartzman | 17 | 3 | |
 United States | Maxime Cressy | 34 | 4 | |
| Botic van de Zandschulp | 35 | 5 | ||
| Aslan Karatsev | 39 | 6 | ||
 France | Adrian Mannarino | 47 | 7 | |
| Tallon Griekspoor | 48 | 8 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
Benjamin Bonzi → replaced by Hugo Grenier J. J. Wolf
Alex Molčan → replaced by Tomás Martín Etcheverry Tommy Paul → replaced by Constant Lestienne
Albert Ramos Viñolas → replaced by 
Vasek Pospisil| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| India | Rohan Bopanna | Matwé Middelkoop | 45 | 1 | ||
| Kevin Krawietz | Andreas Mies | 60 | 2 | |||
| Mexico | Santiago González | Argentina | Andrés Molteni | 68 | 3 | |
| Ariel Behar | Argentina | Máximo González | 93 | 4 |
The following pairs received wildcards into the doubles main draw:
The following pair received entry as alternates:
Benjamin Bonzi / Arthur Rinderknech → replaced by 
Marco Bortolotti / Sergio Martos Gornés Tomás Martín Etcheverry / Albert Ramos Viñolas → replaced by Novak Djokovic / 
Jonathan Erlich
