| Before Year: | 2020 |
| Champ: | João Sousa |
| Runner: |  Emil Ruusuvuori |
| Score: | 7–6(11–9), 4–6, 6–1 |
| Draw: | 28 (3Q, 4WC) |
| Type: | Singles Doubles |
| Seeds: | 8 |
| Main Name: | Maharashtra Open |
See main article: 2022 Tata Open Maharashtra.
João Sousa defeated Emil Ruusuvuori in the final, 7–6(11–9), 4–6, 6–1 to win the singles title at the 2022 Tata Open Maharashtra. Sousa saved three match points against Elias Ymer in the semifinals. This was his first title since 2018.
Jiří Veselý was the defending champion from when the tournament was last held in 2020,[1] but lost in the quarterfinals to Ruusuvuori.
The top four seeds received a bye into the second round.