| Date: | 18–24 April |
| Edition: | 22nd |
| Surface: | Green clay |
| Location: | Tallahassee, Florida, United States |
| Champs: | Wu Tung-lin |
| Champd: | Gijs Brouwer /  Christian Harrison |
The 2022 Tallahassee Tennis Challenger was a professional tennis tournament played on green clay courts. It was the 22nd edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Tallahassee, Florida, United States between April 18 and April 24, 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Tomás Martín Etcheverry | 95 | 1 | |
| United States | Steve Johnson | 107 | 2 | |
 Colombia | Daniel Elahi Galán | 128 | 3 | |
 Ecuador | Emilio Gómez | 131 | 4 | |
| Tomás Barrios Vera | 144 | 5 | ||
| United States | J. J. Wolf | 151 | 6 | |
| United States | Mitchell Krueger | 153 | 7 | |
| United States | Tennys Sandgren | 165 | 8 |
The following players received wildcards into the singles main draw:
Antoine Cornut Chauvinc Aleksandar Kovacevic Alex RybakovThe following players received entry from the qualifying draw:
Daniel Dutra da Silva Arthur Fils Christian Langmo
Jonathan MridhaSee main article: 2022 Tallahassee Tennis Challenger – Singles.
Michael Mmoh 6–3, 6–4.See main article: 2022 Tallahassee Tennis Challenger – Doubles.
Christian Harrison def. Diego Hidalgo / Cristian Rodríguez 4–6, 7–5, [10–6].