See main article: 2022 Sydney Tennis Classic.
Aslan Karatsev defeated Andy Murray in the final, 6–3, 6–3 to win the men's singles title at the 2022 Sydney Tennis Classic. This was Murray's first ATP final since he won the 2019 European Open.[1]
Alex de Minaur was the defending champion from when the event was held in 2019, but withdrew before the tournament began.[2]
The top four seeds receive a bye into the second round.