| Date: | 18–24 April |
| Category: | ATP Challenger Tour |
| Location: | Prague, Czech Republic |
| Surface: | Clay |
| Champs: |  Sebastian Ofner |
| Champd: | Francisco Cabral /  Szymon Walków |
| Before Name: | TK Sparta Prague Open |
| Main Name: | Sparta Prague Open Challenger |
The 2022 Sparta Prague Open was a professional tennis tournament played on clay courts. It was part of the 2022 ATP Challenger Tour. It took place in Prague, Czech Republic between 18 and 24 April 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Daniel Altmaier | 67 | 1 | ||
| Mats Moraing | 124 | 2 | ||
| Tseng Chun-hsin | 125 | 3 | ||
 France | Lucas Pouille | 138 | 4 | |
| Austria | Dennis Novak | 146 | 5 | |
 Czech Republic | Tomáš Macháč | 152 | 6 | |
| Czech Republic | ||||
| Austria | Jurij Rodionov | 167 | 8 | |
 Kazakhstan | Dmitry Popko | 173 | 9 |
The following players received wildcards into the singles main draw:
Jonáš Forejtek Martin Krumich Michael VrbenskýThe following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
See main article: 2022 Sparta Prague Open – Singles.
Sebastian Ofner def. Dalibor Svrčina 6–0, 6–4.See main article: 2022 Sparta Prague Open – Doubles.
Szymon Walków def. Tristan Lamasine / Lucas Pouille 6–2, 7–6(14–12).
David Ionel