| Year: | 2022 |
| Team: | Southern Illinois Salukis |
| Sport: | football |
| Conference: | Missouri Valley Football Conference |
| Short Conf: | MVFC |
| Record: | 5–6 |
| Conf Record: | 4–4 |
| Head Coach: | Nick Hill |
| Hc Year: | 7th |
| Off Coach: | Blake Rolan |
| Oc Year: | 4th |
| Def Coach: | Jason Petrino |
| Dc Year: | 4th |
| Stadium: | Saluki Stadium |
The 2022 Southern Illinois Salukis football team represented Southern Illinois University Carbondale as a member of the Missouri Valley Football Conference (MVFC) during the 2022 NCAA Division I FCS football season. Led by seventh-year head coach Nick Hill, the Salukis played their home games at Saluki Stadium in Carbondale, Illinois.