| Date: | 26 September – 2 October |
| Edition: | 7th |
| Category: | ATP World Tour 250 series |
| Prize Money: | €534,555 |
| Draw: | 28S / 16D |
| Surface: | Hard (indoor) |
| Location: | Sofia, Bulgaria |
| Venue: | Arena Armeec |
| Champs: | Marc-Andrea Hüsler |
| Champd: |  Rafael Matos /  David Vega Hernández |
| Main Name: | ATP Sofia Open Sofia Open |
The 2022 Sofia Open was a tennis tournament to be played on indoor hard courts. It was the 7th edition of the event and it was part of the ATP World Tour 250 series of the 2022 ATP Tour. It was played at the Arena Armeec in Sofia, Bulgaria, from 26 September to 2 October 2022.[1]
See main article: 2022 Sofia Open – Singles.
See main article: 2022 Sofia Open – Doubles.
Rafael Matos / David Vega Hernández def. Fabian Fallert / Oscar Otte, 3–6, 7–5, [10–8]| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Jannik Sinner | 11 | 1 | ||
| Spain | Pablo Carreño Busta | 14 | 2 | |
| Grigor Dimitrov | 23 | 3 | ||
 Italy | Lorenzo Musetti | 30 | 4 | |
| Holger Rune | 31 | 5 | ||
 Georgia | Nikoloz Basilashvili | 36 | 6 | |
 United Kingdom | ||||
| Oscar Otte | 52 | 8 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
Alexander Bublik → replaced by Fernando Verdasco Roberto Carballés Baena → replaced by 
Dušan Lajović Alejandro Davidovich Fokina → replaced by Marc-Andrea Hüsler Jack Draper → replaced by 
Mirza Bašić
Hubert Hurkacz → replaced by Nuno Borges Filip Krajinović → replaced by 
Mikael Ymer
Gaël Monfils → replaced by Kamil Majchrzak
Aleksandar Vukic| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Italy | Simone Bolelli | Italy | Fabio Fognini | 50 | 1 | |
| Brazil | Rafael Matos | Spain | David Vega Hernández | 75 | 2 | |
| Francisco Cabral | United Kingdom | Jamie Murray | 77 | 3 | ||
| Hugo Nys | Poland | Jan Zieliński | 84 | 4 |
The following pairs received wildcards into the doubles main draw:
The following pair received entry as alternates:
Alexander Bublik / Lorenzo Musetti → replaced by 
Jack Vance / Jamie Vance Roberto Carballés Baena / Bernabé Zapata Miralles → replaced by Marc-Andrea Hüsler / Bernabé Zapata Miralles