| Date: | 7–13 November (men) 14–20 November (women) |
| Edition: | 24th (men) 9th (women) |
| Category: | ATP Challenger Tour ITF Women's World Tennis Tour |
| Surface: | Hard (Indoor) |
| Location: | Bratislava, Slovakia |
| Champms: |  Márton Fucsovics |
| Champmd: |  Denys Molchanov /  Aleksandr Nedovyesov |
| Champws: | Ana Konjuh |
| Champwd: |  Jesika Malečková / Renata Voráčová |
| Before Name: | Slovak Open II |
The 2022 Slovak Open was a professional tennis tournament played on hard courts. It was the 24th edition of the tournament which was part of the 2022 ATP Challenger Tour and the ninth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Bratislava, Slovakia between 7 and 20 November 2022.
See main article: 2022 Slovak Open – Men's singles.
Márton Fucsovics def. Fábián Marozsán 6–2, 6–4.See main article: 2022 Slovak Open – Women's singles.
Nigina Abduraimova, 2–6, 6–0, 7–6(7–2)See main article: 2022 Slovak Open – Men's doubles.
Denys Molchanov / Aleksandr Nedovyesov def. Petr Nouza / Andrew Paulson 4–6, 6–4, [10–6].See main article: 2022 Slovak Open – Women's doubles.
Jesika Malečková / Renata Voráčová def. 
Katarína Kužmová / Viktória Kužmová, 2–6, 7–5, [13–11]| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 China | Zhang Zhizhen | 99 | 1 | |
| Hungary | Márton Fucsovics | 103 | 2 | |
| Slovakia | Norbert Gombos | 111 | 3 | |
| Czech Republic | Tomáš Macháč | 114 | 4 | |
| Tim van Rijthoven | 115 | 5 | ||
 Austria | Jurij Rodionov | 130 | 6 | |
| Jelle Sels | 131 | 7 | ||
| Slovakia | Jozef Kovalík | 133 | 8 |
The following players received wildcards into the singles main draw:
Jakub Menšík Lukáš Pokorný Peter Benjamín PrivaraThe following players received entry from the qualifying draw:
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Slovakia | Anna Karolína Schmiedlová | 100 | 1 | |
| Ukraine | Daria Snigur | 106 | 2 | |
| Eva Lys | 123 | 3 | ||
| Ana Konjuh | 136 | 4 | ||
| Slovakia | Viktória Kužmová | 146 | 5 | |
 Romania | Jaqueline Cristian | 148 | 6 | |
| Romania | Alexandra Cadanțu-Ignatik | 171 | 7 | |
| Uzbekistan | Nigina Abduraimova | 192 | 8 |
The following players received wildcards into the singles main draw:
Irina Balus Nikola Daubnerová Renáta Jamrichová Nina VargováThe following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
Freya Christie Denisa Hindová Anika Jašková Aneta Kučmová Katarína Kužmová Eszter Méri Amarissa Kiara TóthThe following player received entry as a lucky loser:
