The 2022 Sibiu Open was a professional tennis tournament played on clay courts. It was the eleventh edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Sibiu, Romania between 19 and 25 September 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Federico Coria | 71 | 1 | |
 Austria | Filip Misolic | 145 | 2 | |
 Czech Republic | Zdeněk Kolář | 156 | 3 | |
| Argentina | Thiago Agustín Tirante | 171 | 4 | |
 Italy | Riccardo Bonadio | 174 | 5 | |
 Bosnia and Herzegovina | Damir Džumhur | 193 | 6 | |
 Belgium | Kimmer Coppejans | 200 | 7 | |
 Serbia | Nikola Milojević | 207 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
Steven Diez Giovanni Fonio
Georgii KravchenkoSee main article: 2022 Sibiu Open – Singles.
Nerman Fatić def. Damir Džumhur 6–3, 6–4.See main article: 2022 Sibiu Open – Doubles.
Ivan Sabanov / Matej Sabanov def. Alexander Erler / Lucas Miedler 3–6, 7–5, [10–4].
