| Date: | 9–14 May |
| Edition: | 5th |
| Surface: | Clay |
| Location: | Shymkent, Kazakhstan |
| Champs: |  Emilio Nava |
| Champd: | Antoine Bellier /  Gabriel Décamps |
| Before Name: | Shymkent Challenger II |
| Before Year: | 2019 |
| After Name: | Shymkent Challenger II |
| After Year: | 2022 |
The 2022 Shymkent Challenger was a professional tennis tournament played on clay courts. It was the fifth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Shymkent, Kazakhstan between 9 and 14 May 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| United States | Tennys Sandgren | 179 | 1 | |
 Turkey | Altuğ Çelikbilek | 184 | 2 | |
| Alexander Shevchenko | 248 | 3 | ||
 Ukraine | Illya Marchenko | 251 | 4 | |
 Spain | Nicolás Álvarez Varona | 278 | 5 | |
 Japan | Kaichi Uchida | 282 | 6 | |
| Evgeny Karlovskiy | 286 | 7 | ||
 Romania | Filip Jianu | 298 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw using protected rankings:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Mukund Sasikumar Eric Vanshelboim Evan ZhuSee main article: 2022 Shymkent Challenger – Singles.
Emilio Nava def. Sebastian Fanselow 6–4, 7–6(7–3).See main article: 2022 Shymkent Challenger – Doubles.
Gabriel Décamps def. Sebastian Fanselow / Kaichi Uchida 7–6(7–3), 6–3.
