See main article: article and 2022 Serbia Open.
Andrey Rublev defeated Novak Djokovic in the final, 6–2, 6–7(4–7), 6–0 to win the singles tennis title at the 2022 Serbia Open.
Matteo Berrettini was the reigning champion,[1] but chose not to defend his title.
The top four seeds received a bye into the second round.