| Date: | 10 – 16 October |
| Edition: | 6th |
| Location: | Seoul, South Korea |
| Champs: |  Li Tu |
| Champd: |  Kaichi Uchida / Wu Tung-lin |
| Before Year: | 2019 |
The 2022 Seoul Open Challenger was a professional tennis tournament played on outdoor hard courts. It was the sixth edition of the tournament. It was part of the 2022 ATP Challenger Tour. It took place in Seoul, South Korea, between 10 and 16 October 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Moldova, Republic of | Radu Albot | 86 | 1 | |
| Tseng Chun-hsin | 87 | 2 | ||
| Australia | Alexei Popyrin | 93 | 3 | |
 Ecuador | Emilio Gómez | 102 | 4 | |
| Australia | Christopher O'Connell | 106 | 5 | |
| Australia | James Duckworth | 109 | 6 | |
 United States | Steve Johnson | 112 | 7 | |
 Poland | Kamil Majchrzak | 121 | 8 |
The following players received wildcards into the singles main draw:
Chung Hong Kim Cheong-eui Kim Jang-junThe following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
See main article: 2022 Seoul Open Challenger – Singles.
See main article: 2022 Seoul Open Challenger – Doubles.
Kaichi Uchida / Wu Tung-lin def. Chung Yun-seong / Aleksandar Kovacevic 6–7(2–7), 7–5, [11–9].
