The 2022 Savannah Challenger was a professional tennis tournament played on clay courts. It was the twelfth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Savannah, Georgia, United States between April 25 and May 1, 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Tomás Martín Etcheverry | 95 | 1 | |
 United States | 123 | 2 | ||
 Ecuador | Emilio Gómez | 130 | 3 | |
| United States | Jack Sock | 139 | 4 | |
| 141 | 5 | |||
| United States | J. J. Wolf | 145 | 6 | |
| United States | Tennys Sandgren | 170 | 7 | |
| United States | Bjorn Fratangelo | 176 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Ezekiel Clark
Arthur Fils Strong Kirchheimer Aidan Mayo Govind Nanda
José PereiraSee main article: 2022 Savannah Challenger – Singles.
Jack Sock def. Christian Harrison 6–4, 6–1.See main article: 2022 Savannah Challenger – Doubles.
Zhang Zhizhen 7–6(7–3), 6–4.