The 2022 Sarasota Open was a professional tennis tournament played on clay courts. It was the 12th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Sarasota, Florida, United States between April 11 and April 17, 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 United States | Denis Kudla | 81 | 1 | |
 Australia | ||||
| Alejandro Tabilo | 100 | 3 | ||
| United States | Steve Johnson | 108 | 4 | |
 Colombia | Daniel Elahi Galán | 121 | 5 | |
 Argentina | Juan Ignacio Londero | 131 | 6 | |
| United States | Jack Sock | 138 | 7 | |
| Tomás Barrios Vera | 144 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
See main article: 2022 Sarasota Open – Singles.
Daniel Elahi Galán def. Steve Johnson 7–6(9–7), 4–6, 6–1.See main article: 2022 Sarasota Open – Doubles.
Robert Galloway / Jackson Withrow def. 
André Göransson / Nathaniel Lammons 6–3, 7–6(7–3).
