See main article: 2022 Santa Cruz Challenger II.
Diego Hidalgo and Cristian Rodríguez were the defending champions[1] but lost in the semifinals to Jesper de Jong and Bart Stevens.
De Jong and Stevens won the title after defeating Nicolás Barrientos and Miguel Ángel Reyes-Varela 6–4, 3–6, [10–6] in the final.