| Champ: | Antoine Bellier |
| Runner: |  Renzo Olivo |
| Score: | 6–7(2–7), 6–4, 7–5 |
| Type: | singles doubles |
| Before Year: | 2019 |
| Before Name: | San Luis Open Challenger Tour |
| After Name: | San Luis Open Challenger – Men's singles |
See main article: 2022 San Luis Open Challenger.
Marc-Andrea Hüsler was the defending champion[1] but lost in the semifinals to Antoine Bellier.
Bellier won the title after defeating Renzo Olivo 6–7(2–7), 6–4, 7–5 in the final.