See main article: 2022 San Diego Open.
Iga Świątek defeated Donna Vekić in the final, 6–3, 3–6, 6–0 to win the women's singles tennis title at the 2022 San Diego Open. It was her eighth title of the 2022 season. By winning the title, Świątek became the first player since Serena Williams in 2013 to win more than 10,000 ranking points in a single season.
This was the first WTA Tour-level event to be held in the San Diego area since 2013.[1]
The top four seeds received a bye into the second round.