The 2022 San Diego Open was a combined men's and women's tennis tournament played on outdoor hard courts. It was the 2nd edition of the event for the men and the 1st edition of the Southern California Open for the women since 2015. The event is part of the ATP Tour 250 series of the 2022 ATP Tour and a WTA 500 event on the 2022 WTA Tour. It was held at the Barnes Tennis Center in San Diego, United States, from September 19 through September 25, 2022 for the men, and from October 10 through October 16, 2022 for the women.[1]
The event was primarily organized being held on a second consecutive year in the alternative sporting calendar due to the cancellation of tournaments in China during the 2022 season because of the ongoing COVID-19 pandemic, as well as the WTA's suspension of tournaments in China following former WTA player Peng Shuai's allegation of sexual assault against a Chinese government official.[2] [3] [4]
See main article: 2022 San Diego Open – Men's singles.
Brandon Nakashima def. Marcos Giron, 6–4, 6–4See main article: 2022 San Diego Open – Women's singles.
Iga Świątek def. Donna Vekić, 6–3, 3–6, 6–0This is Świątek's eighth title of the year and eleventh of her career.
See main article: 2022 San Diego Open – Men's doubles.
Nathaniel Lammons / Jackson Withrow def. 
Jason Kubler / Luke Saville, 7–6(7–5), 6–2See main article: 2022 San Diego Open – Women's doubles.
Coco Gauff / Jessica Pegula def. 
Gabriela Dabrowski / 
Giuliana Olmos, 1–6, 7–5, [10–4]| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 United Kingdom | Dan Evans | 25 | 1 | |
| United States | Jenson Brooksby | 50 | 2 | |
| United States | Marcos Giron | 60 | 3 | |
 Spain | Pedro Martínez | 67 | 4 | |
| United States | Brandon Nakashima | 68 | 5 | |
| Alejandro Tabilo | 69 | 6 | ||
| Australia | James Duckworth | 70 | 7 | |
| United States | J. J. Wolf | 72 | 8 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
Jason Kubler Steve Johnson
Kwon Soon-woo → replaced by Stefan Kozlov
Jiří Veselý → replaced by Christopher O'Connell| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Mexico | Santiago González |  Argentina | Andrés Molteni | 65 | 1 | |
| United States | Nathaniel Lammons | United States | Jackson Withrow | 129 | 2 | |
 Colombia | Nicolás Barrientos | Mexico | Miguel Ángel Reyes-Varela | 146 | 3 | |
 Sweden | André Göransson |  Japan | Ben McLachlan | 147 | 4 |
The following pairs received wildcards into the doubles main draw:
The following pair received entry as alternates:
William Blumberg / Alejandro Tabilo → replaced by Evan King / Denis Kudla Robert Galloway / Alex Lawson → replaced by 
Jonathan Eysseric / 
Artem Sitak Cristian Garín / Hans Hach Verdugo → replaced by Hans Hach Verdugo / Treat Huey Max Purcell / Luke Saville → replaced by Jason Kubler / Luke Saville| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Poland | Iga Świątek | 1 | 1 | |
| Spain | Paula Badosa | 4 | 2 | |
| Aryna Sabalenka | 5 | 3 | ||
| United States | Jessica Pegula | 6 | 4 | |
| Maria Sakkari | 7 | 5 | ||
| United States | Coco Gauff | 8 | 6 | |
| France | Caroline Garcia | 10 | 7 | |
| Daria Kasatkina | 11 | 8 |
The following players received wildcards into the main draw:
The following players used a protected ranking to enter the main draw:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Beatriz Haddad Maia → replaced by Liudmila Samsonova
Anett Kontaveit → replaced by Bianca Andreescu Petra Kvitová → replaced by 
Martina Trevisan Alison Riske-Amritraj
Elena Rybakina → replaced by 
Zheng Qinwen| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| United States | Coco Gauff | United States | Jessica Pegula | 11 | 1 | |
| Canada | Gabriela Dabrowski | Mexico | Giuliana Olmos | 15 | 2 | |
| United States | Nicole Melichar-Martinez | Australia | Ellen Perez | 27 | 3 | |
| United States | Desirae Krawczyk | Demi Schuurs | 28 | 4 |
The following pair received a wildcard into the doubles main draw:
Alyssa Ahn / Katherine Hui Anna Danilina / Beatriz Haddad Maia → replaced by Anna Danilina / Aliaksandra Sasnovich