The 2022 Salzburg Open was a professional tennis tournament played on outdoor clay courts. It was the second edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Anif (Salzburg), Austria between 4 and 10 July 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 France | Arthur Rinderknech | 62 | 1 | |
 Serbia | Dušan Lajović | 64 | 2 | |
 Czech Republic | Jiří Lehečka | 72 | 3 | |
 Spain | Roberto Carballés Baena | 87 | 4 | |
 Sweden | Mikael Ymer | 88 | 5 | |
 Brazil | Thiago Monteiro | 89 | 6 | |
 Argentina | Facundo Bagnis | 102 | 7 | |
| Spain | Fernando Verdasco | 115 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following player received entry into the singles main draw as a special exempt:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
Pol Martín TiffonSee main article: 2022 Salzburg Open – Singles.
Thiago Monteiro def. 
Norbert Gombos 6–3, 7–6(7–2).See main article: 2022 Salzburg Open – Doubles.
Nathaniel Lammons / Jackson Withrow def. 
Alexander Erler / Lucas Miedler 7–5, 5–7, [11–9].
