| Date: | 10 – 16 October |
| Edition: | 2nd |
| Surface: | Hard |
| Location: | Saint-Tropez, France |
| Champs: |  Mattia Bellucci |
| Champd: |  Dan Added / Albano Olivetti |
The 2022 Saint-Tropez Open was a professional tennis tournament played on hard courts. It was the second edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Saint-Tropez, France between 10 and 16 October 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| France | ||||
| France | Hugo Grenier | 101 | 2 | |
| France | Ugo Humbert | 104 | 3 | |
 Spain | Fernando Verdasco | 115 | 4 | |
| France | Grégoire Barrère | 116 | 5 | |
 United States | Jack Sock | 122 | 6 | |
 Austria | Jurij Rodionov | 135 | 7 | |
| France | Geoffrey Blancaneaux | 142 | 8 | |
| Alexander Shevchenko | 146 | 9 |
The following players received wildcards into the singles main draw:
Dan Added Jurgen Briand Luca Van AsscheThe following player received entry into the singles main draw using a protected ranking:
The following player received entry into the singles main draw as a special exempt:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2022 Saint-Tropez Open – Singles.
Mattia Bellucci def. Matteo Arnaldi 6–3, 6–3.See main article: 2022 Saint-Tropez Open – Doubles.
Dan Added / Albano Olivetti def. Romain Arneodo / Tristan-Samuel Weissborn 6–3, 3–6, [12–10].
