| Date: | 14–20 November |
| Edition: | 3rd |
| Location: | São Leopoldo, Brazil |
| Champs: |  Juan Pablo Varillas |
| Champd: |  Guido Andreozzi / Guillermo Durán |
| Before Year: | 2012 |
| After Year: | 2024 |
The 2022 São Léo Open was a professional tennis tournament played on clay courts. It was the 3rd edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in São Leopoldo, Brazil between 14 and 20 November 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Argentina | Facundo Bagnis | 103 | 1 | |
| Peru | Juan Pablo Varillas | 116 | 2 | |
 Italy | Franco Agamenone | 154 | 3 | |
 Brazil | Felipe Meligeni Alves | 164 | 4 | |
| Argentina | Renzo Olivo | 186 | 5 | |
| Argentina | Facundo Díaz Acosta | 188 | 6 | |
| Brazil | Matheus Pucinelli de Almeida | 199 | 7 | |
| Gastão Elias | 214 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Mateus Alves
Leo Borg Wilson Leite Juan Pablo PazThe following player received entry as a lucky loser:
See main article: 2022 São Léo Open – Singles.
Juan Pablo Varillas def. Facundo Bagnis 7–6(7–5), 4–6, 6–4.See main article: 2022 São Léo Open – Doubles.
Guido Andreozzi / Guillermo Durán def. Felipe Meligeni Alves / João Lucas Reis da Silva 5–1 ret.