The 2022 República Dominicana Open was a professional tennis tournament played on green clay courts. It was the sixth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Santo Domingo, Dominican Republic between 15 and 21 August 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Spain | Roberto Carballés Baena | 78 | 1 | |
 Argentina | Pedro Cachin | 87 | 2 | |
| Argentina | Tomás Martín Etcheverry | 94 | 3 | |
 Colombia | Daniel Elahi Galán | 97 | 4 | |
 Peru | Juan Pablo Varillas | 100 | 5 | |
| Argentina | Camilo Ugo Carabelli | 121 | 6 | |
| Argentina | Federico Delbonis | 133 | 7 | |
| Argentina | Facundo Mena | 138 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Nicolás Barrientos
Pedro Boscardin Dias Román Andrés Burruchaga Facundo Juárez
Patrick Kypson Nicolás MejíaThe following player received entry as a lucky loser:
See main article: 2022 República Dominicana Open – Singles.
Pedro Cachin def. Marco Trungelliti 6–4, 2–6, 6–3.See main article: 2022 República Dominicana Open – Doubles.
Reese Stalder def. Nicolás Barrientos / 
Miguel Ángel Reyes-Varela 7–6(7–5), 6–3.
