See main article: 2022 Queen's Club Championships.
| Champ: |  Matteo Berrettini |
| Runner: |  Filip Krajinović |
| Score: | 7–5, 6–4 |
| Draw: | 32 (4 / 3) |
| Seeds: | 8 |
| Type: | queensclubtennistournament |
Defending champion Matteo Berrettini defeated Filip Krajinović in the final, 7–5, 6–4 to win the singles tennis title at the 2022 Queen's Club Championships. By winning his fourth title on grass and seventh career ATP Tour singles title overall, Berrettini became the first player in the Open Era to claim the title in their first two appearances at the tournament. Krajinović had never earned a tour-level win on grass before the tournament and was seeking his first career title in his fifth final.[1]