| Date: | 21–27 March |
| Edition: | 4th |
| Surface: | Hard (indoor) |
| Location: | Lille, France |
| Champs: |  Quentin Halys |
| Champd: |  Viktor Durasovic /  Patrik Niklas-Salminen |
The 2022 Play In Challenger was a professional tennis tournament played on indoor hard courts. It was the fourth edition of the tournament, which was part of the 2022 ATP Challenger Tour. It took place in Lille, France, between 21 and 27 March 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Lithuania | Ričardas Berankis | 84 | 1 | |
| France | Quentin Halys | 113 | 2 | |
 Bosnia and Herzegovina | Damir Džumhur | 137 | 3 | |
| Roman Safiullin | 143 | 4 | ||
| France | Grégoire Barrère | 172 | 5 | |
| France | Enzo Couacaud | 181 | 6 | |
 Belgium | Zizou Bergs | 182 | 7 | |
| France | Constant Lestienne | 198 | 8 |
The following players received wildcards into the singles main draw:
Simon Beaupain Sean Cuenin Sascha Gueymard WayenburgThe following players received entry into the singles main draw using protected rankings:
The following players received entry from the qualifying draw:
See main article: 2022 Play In Challenger – Singles.
Quentin Halys def. Ričardas Berankis 4–6, 7–6(7–4), 6–4.See main article: 2022 Play In Challenger – Doubles.
Viktor Durasovic / Patrik Niklas-Salminen def. Jonathan Eysseric / Quentin Halys 7–5, 7–6(7–1).
