| Year: | 2022 |
| Team: | Penn Quakers |
| Sport: | football |
| Conference: | Ivy League |
| Short Conf: | Ivy |
| Record: | 8–2 |
| Conf Record: | 5–2 |
| Head Coach: | Ray Priore |
| Hc Year: | 7th |
| Off Coach: | Dan Swanstrom |
| Oc Year: | 1st |
| Def Coach: | Bob Benson |
| Dc Year: | 7th |
| Stadium: | Franklin Field |
The 2022 Penn Quakers football team represented the University of Pennsylvania as a member of the Ivy League during the 2022 NCAA Division I FCS football season. The team was led by seventh-year head coach Ray Priore and played its home games at Franklin Field.
See also: 2022 Colgate Raiders football team.
See also: 2022 Lafayette Leopards football team.
See also: 2022 Dartmouth Big Green football team.
See also: 2022 Georgetown Hoyas football team.
See also: 2022 Columbia Lions football team.
See also: 2022 Yale Bulldogs football team.
See also: 2022 Brown Bears football team.
See also: 2022 Cornell Big Red football team and Cornell–Penn football rivalry.
See also: 2022 Harvard Crimson football team and Harvard–Penn football rivalry.
See also: 2022 Princeton Tigers football team and Penn–Princeton football rivalry.