| Champ: |  Barbora Krejčíková |
| Runner: |  Iga Świątek |
| Score: | 5–7, 7–6(7–4), 6–3 |
| Draw: | 28 |
| Seeds: | 8 |
| Type: | singles doubles |
| Before Name: | J&T Banka Ostrava Open – Singles |
| After Year: | no |
See main article: article and 2022 Ostrava Open.
Barbora Krejčíková defeated Iga Świątek in the final, 5–7, 7–6(7–4), 6–3 to win the singles tennis title at the 2022 Ostrava Open.[1] [2] It was Krejčíková's second WTA Tour title in back-to-back weeks, and she ended Świątek's streak of ten consecutive victories in WTA Tour finals. This marked only Świątek's second career loss in a WTA Tour-level final, out of twelve played (the other being at the 2019 Ladies Open Lugano).
Anett Kontaveit was the defending champion,[3] but retired in the second round against Tereza Martincová.
The top four seeds received a bye into the second round.