| Date: | June 6–12 |
| Edition: | 5th |
| Surface: | Hard |
| Location: | Orlando, Florida, United States |
| Champs: |  Wu Yibing |
| Champd: |  Chung Yun-seong / Michail Pervolarakis |
| Before Name: | Orlando Open II |
The 2022 Orlando Open was a professional tennis tournament played on hard courts. It was the fifth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Orlando, Florida, United States between June 6 and 12 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 United States | J. J. Wolf | 125 | 1 | |
 Ecuador | Emilio Gómez | 151 | 2 | |
| United States | Christopher Eubanks | 156 | 3 | |
 Australia | Jason Kubler | 159 | 4 | |
| United States | Michael Mmoh | 175 | 5 | |
 Turkey | Altuğ Çelikbilek | 179 | 6 | |
| United States | Bjorn Fratangelo | 185 | 7 | |
| Australia | Rinky Hijikata | 233 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw using protected rankings:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Martin Damm
Gilbert Klier Júnior Keegan SmithSee main article: 2022 Orlando Open – Singles.
Wu Yibing def. Jason Kubler 6–7(5–7), 6–4, 3–1 ret.See main article: 2022 Orlando Open – Doubles.
Chung Yun-seong / Michail Pervolarakis def. 
Malek Jaziri / 
Kaichi Uchida 6–7(5–7), 7–6(7–3), [16–14].