| Date: | 2–8 May |
| Edition: | 9th |
| Surface: | Clay |
| Location: | Aix-en-Provence, France |
| Champd: |  Titouan Droguet / Kyrian Jacquet |
| After Name: | Open Aix Provence |
The 2022 Open du Pays d'Aix was a professional tennis tournament played on clay courts. It was the ninth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Aix-en-Provence, France between 2 and 8 May 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| France | Benjamin Bonzi | 58 | 1 | |
| Daniel Altmaier | 67 | 2 | ||
| France | Richard Gasquet | 80 | 3 | |
| France | Quentin Halys | 102 | 4 | |
| Pablo Cuevas | 107 | 5 | ||
 Peru | Juan Pablo Varillas | 111 | 6 | |
 Spain | Fernando Verdasco | 118 | 7 | |
| France | Corentin Moutet | 120 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
See main article: 2022 Open du Pays d'Aix – Singles.
Benjamin Bonzi def. Grégoire Barrère 6–2, 6–4.See main article: 2022 Open du Pays d'Aix – Doubles.
Titouan Droguet / Kyrian Jacquet def. 
Nicolás Barrientos / 
Miguel Ángel Reyes-Varela 6–2, 6–3.