| Date: | 28 March–4 April |
| Edition: | 5th |
| Surface: | Clay |
| Location: | Oeiras, Portugal |
| Champs: | Gastão Elias |
| Champd: | Nuno Borges / Francisco Cabral |
| Before Name: | Open de Oeiras IV |
| After Name: | Open de Oeiras II |
| After Year: | 2022 |
The 2022 Open de Oeiras was a professional tennis tournament played on clay courts. It was the fifth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Oeiras, Portugal between 28 March and 4 April 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 France | ||||
 Italy | Gianluca Mager | 99 | 2 | |
| Italy | Stefano Travaglia | 113 | 3 | |
 Brazil | Thiago Monteiro | 116 | 4 | |
 Czech Republic | Zdeněk Kolář | 137 | 5 | |
| Nuno Borges | 150 | 6 | ||
| Czech Republic | Vít Kopřiva | 164 | 7 | |
| Italy | Alessandro Giannessi | 174 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as a special exempt:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Luciano Darderi
Ergi Kırkın Matthieu Perchicot
Noah Rubin Alex RybakovThe following player received entry as a lucky loser:
See main article: 2022 Open de Oeiras – Singles.
See main article: 2022 Open de Oeiras – Doubles.
Sanjar Fayziev / Markos Kalovelonis 6–3, 6–0.