| Date: | 26 September – 2 October |
| Edition: | 17th |
| Surface: | Hard (Indoor) |
| Location: | Orléans, France |
| Champs: |  Grégoire Barrère |
| Champd: | Nicolas Mahut / Édouard Roger-Vasselin |
The 2022 Open d'Orléans was a professional tennis tournament played on indoor hard courts. It was the seventeenth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Orléans, France between 26 September and 2 October 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| France | Corentin Moutet | 64 | 1 | |
| France | Hugo Gaston | 79 | 2 | |
| France | Richard Gasquet | 85 | 3 | |
| France | Quentin Halys | 86 | 4 | |
 Hungary | Márton Fucsovics | 91 | 5 | |
 Slovakia | Norbert Gombos | 101 | 6 | |
| Henri Laaksonen | 125 | 7 | ||
 United States | Jack Sock | 128 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as special exempts:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
See main article: 2022 Open d'Orléans – Singles.
Grégoire Barrère def. Quentin Halys 4–6, 6–3, 6–4.See main article: 2022 Open d'Orléans – Doubles.
Nicolas Mahut / Édouard Roger-Vasselin def. 
Michael Geerts / 
Skander Mansouri 6–2, 6–4.
