See main article: 2022 Open Sud de France. Alexander Bublik defeated Alexander Zverev in the final, 6–4, 6–3 to win the singles title at the 2022 Open Sud de France. It was his maiden ATP Tour title.
David Goffin was the defending champion,[1] but lost to Adrian Mannarino in the second round.
| Before Year: | 2021 |
| Champ: |  Alexander Bublik |
| Runner: | Alexander Zverev |
| Score: | 6–4, 6–3 |
| Draw: | 28 (4Q, 3WC) |
| Seeds: | 8 |
| Type: | Singles Doubles |
| After Year: | 2023 |
The top four seeds received a bye into the second round.