| Champ: |  Pierre-Hugues Herbert Nicolas Mahut |
| Runner: |  Lloyd Glasspool Harri Heliövaara |
| Score: | 4–6, 7–6(7–3), [12–10] |
| Draw: | 16 |
| Seeds: | 4 |
| Type: | singles doubles |
See main article: 2022 Open Sud de France.
Pierre-Hugues Herbert and Nicolas Mahut defeated Lloyd Glasspool and Harri Heliövaara in the final, 4–6, 7–6(7–3), [12–10] to win the doubles tennis title at the 2022 Open Sud de France. They saved a championship point en route to their 21st career ATP Tour doubles title together. Glasspool and Heliövaara were contesting for their second title as a team.[1]
Henri Kontinen and Édouard Roger-Vasselin were the defending champions,[2] but only Roger-Vasselin returned and partnered with Jonathan Erlich for his title defense. The pair lost in the semifinals to Herbert and Mahut.[3]