| Date: | 13–19 June 2022 |
| Edition: | 8th |
| Surface: | Hard / Outdoor |
| Location: | Madrid, Spain |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Marina Bassols Ribera |
| Champd: |  Anna Danilina / Anastasia Tikhonova |
The 2022 Open ITF Arcadis Brezo Osuna was a professional tennis tournament played on outdoor hard courts. It was the eighth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Madrid, Spain between 13 and 19 June 2022.[1]
See main article: 2022 Open ITF Arcadis Brezo Osuna – Singles.
Marina Bassols Ribera def. Alex Eala, 6–4, 7–5See main article: 2022 Open ITF Arcadis Brezo Osuna – Doubles.
Anna Danilina / Anastasia Tikhonova def. 
Lu Jiajing / You Xiaodi, 6–4, 6–2| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| China | Zhu Lin | 96 | 1 | |
| Anastasia Tikhonova | 175 | 2 | ||
 Australia | Jaimee Fourlis | 177 | 3 | |
| Richèl Hogenkamp | 222 | 4 | ||
 France | Carole Monnet | 258 | 5 | |
 Hungary | Tímea Babos | 262 | 6 | |
| Spain | Yvonne Cavallé Reimers | 277 | 7 | |
| Valeria Savinykh | 282 | 8 | ||
| Stephanie Wagner | 294 | 9 | ||
| China | You Xiaodi | 296 | 10 | |
| Daniela Seguel | 297 | 11 | ||
| Spain | Jéssica Bouzas Maneiro | 305 | 12 | |
| China | Lu Jiajing | 310 | 13 | |
| Spain | Marina Bassols Ribera | 317 | 14 | |
| Liang En-shuo | 322 | 15 | ||
 Canada | Katherine Sebov | 325 | 16 |
The following players received wildcards into the singles main draw:
Ainhoa Atucha Gómez Lucía Cortez Llorca Carolina Gómez Ariana Geerlings Lidia Moreno AriasThe following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
Mana Ayukawa Marta González Encinas Yasmine Mansouri
Sofia Milatová Alana Parnaby Marine Szostak