| Date: | 28 March–4 April |
| Edition: | 17th |
| Surface: | Hard (indoor) |
| Location: | Saint-Brieuc, France |
| Champs: |  Jack Draper |
| Champd: | Sander Arends / David Pel |
| Before Year: | 2019 |
| After Name: | Open Saint-Brieuc |
The 2022 Open Harmonie mutuelle was a professional tennis tournament played on hard courts. It was the seventeenth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Saint-Brieuc, France between 28 March and 4 April 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Lithuania | ||||
 France | Quentin Halys | 115 | 2 | |
| France | Gilles Simon | 139 | 3 | |
| Roman Safiullin | 143 | 4 | ||
| United Kingdom | Jack Draper | 146 | 5 | |
| France | Grégoire Barrère | 178 | 6 | |
| France | Constant Lestienne | 205 | 7 | |
| France | Antoine Hoang | 214 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
See main article: 2022 Open Harmonie mutuelle – Singles.
Jack Draper def. 
Zizou Bergs 6–2, 5–7, 6–4.See main article: 2022 Open Harmonie mutuelle – Doubles.
Jonathan Eysseric / Robin Haase 6–3, 6–3.
