| Date: | 5–11 September |
| Edition: | 1st |
| Draw: | 32S / 16D |
| Category: | WTA 125 |
| Location: | Bari, Italy |
| Venue: | Circolo del Tennis Bari |
| Surface: | Clay |
| Prize Money: | $115,000 |
| Champs: |  Julia Grabher |
| Champd: |  Elisabetta Cocciaretto /  Olga Danilović |
The 2022 Open delle Puglie was a professional tennis tournament played on outdoor clay courts. It was the first edition of the tournament and part of the 2022 WTA 125 tournaments, offering a total of $115,000 in prize money. It took place at the Circolo del Tennis at the Via Martinez in Bari, Italy between 5 and 11 September 2022.[1] [2]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Hungary | Panna Udvardy | 78 | 1 | |
 Montenegro | Danka Kovinić | 80 | 2 | |
| Tatjana Maria | 85 | 3 | ||
 Belgium | Maryna Zanevska | 97 | 4 | |
| Italy | Elisabetta Cocciaretto | 99 | 5 | |
 Brazil | Laura Pigossi | 100 | 6 | |
 France | Harmony Tan | 112 | 7 | |
| Serbia | Olga Danilović | 114 | 8 |
The following players received a wildcard into the singles main draw:
The following players received entry into the main draw through qualification:
The following players entered the main draw as lucky losers:
Kateryna Baindl
Ana Bogdan → replaced by 
Rebeka Masarova Lucia Bronzetti → replaced by Carolina Alves Clara Burel → replaced by Ioana Loredana Roșca
Andrea Gámiz Jasmine Paolini → replaced by 
Jaimee Fourlis Nuria Párrizas Díaz → replaced by Réka Luca Jani
Mayar Sherif → replaced by Dalila Jakupović
Zheng Qinwen → replaced by 
Raluca Șerban| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Venezuela, Bolivarian Republic of | Andrea Gámiz | Eva Vedder | 240 | 1 | ||
 Poland | Paula Kania-Choduń |  Czech Republic | Renata Voráčová | 242 | 2 | |
| Angelina Gabueva | Brazil | Laura Pigossi | 252 | 3 | ||
| Brazil | Carolina Alves |  Argentina | María Lourdes Carlé | 280 | 4 |
The following pair received a wildcard into the doubles main draw:
See main article: 2022 Open Delle Puglie – Singles.
Julia Grabher def. Nuria Brancaccio 6–4, 6–2See main article: 2022 Open Delle Puglie – Doubles.
Elisabetta Cocciaretto / Olga Danilović def. Andrea Gámiz / Eva Vedder 6–2, 6–3