The 2022 Open Bogotá was a professional tennis tournament played on clay courts. It was the fourteenth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Bogotá, Colombia between 4 and 10 July 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Facundo Mena | 160 | 1 | |
| Argentina | Juan Pablo Ficovich | 163 | 2 | |
 Brazil | Felipe Meligeni Alves | 197 | 3 | |
| Argentina | ||||
 Austria | Gerald Melzer | 247 | 5 | |
| Gonzalo Lama | 263 | 6 | ||
 Serbia | Miljan Zekić | 276 | 7 | |
| Argentina | Gonzalo Villanueva | 286 | 8 | |
 United States | Aleksandar Kovacevic | 298 | 9 |
The following players received wildcards into the singles main draw:
Nicolás Buitrago Sergio Luis Hernández Ramírez Andrés UrreaThe following players received entry from the qualifying draw:
Mateus Alves
Blu Baker
Arklon Huertas del Pino Ignacio Monzón
Naoki Nakagawa Matías ZukasThe following player received entry as a lucky loser:
See main article: 2022 Open Bogotá – Singles.
Juan Pablo Ficovich def. Gerald Melzer 6–1, 6–2.See main article: 2022 Open Bogotá – Doubles.
Nicolás Mejía / Andrés Urrea def. Ignacio Monzón / Gonzalo Villanueva 6–3, 6–4.