See main article: 2022 Open 13 Provence.
Andrey Rublev defeated Félix Auger-Aliassime in the final, 7–5, 7–6(7–4) to win the singles title at the 2022 Open 13 Provence.
Daniil Medvedev was the defending champion,[1] but chose not to defend his title.
The top four seeds received a bye into the second round.